Post-ACS discharge medications should typically include which combination?

• A. Antibiotics
• B. Diuretics only
• C. Aspirin, P2Y12 inhibitor, statin, beta-blocker, ACE inhibitor
• D. Calcium channel blocker

Answer: (C)

Post-ACS discharge care aims to prevent reinfarction, reduce mortality, and support heart function by addressing thrombosis, lipid management, remodeling, and symptoms. The combination of aspirin and a P2Y12 inhibitor provides dual antiplatelet therapy to prevent thrombus formation on ruptured plaque or on a stent. A statin is essential to stabilize plaques and lower LDL, improving long-term outcomes after an ACS. A beta-blocker reduces myocardial oxygen demand and helps prevent reinfarction and arrhythmias, provided there are no contraindications. An ACE inhibitor protects against adverse remodeling and lowers mortality risk, especially in patients with reduced LV function, hypertension, or diabetes.

Antibiotics are not a standard part of post-ACS discharge unless an infection is present, and diuretics alone don’t address the primary pathophysiology of ACS. Calcium channel blockers aren’t universally indicated for all post-ACS patients, though they may be used for angina or hypertension in specific cases. The five-drug combination above represents the typical, guideline-supported core regimen for discharge after ACS.